RapamycinFungusV1, Main, Exploration, bibRecord, 000544

More than One Way in: Three Gln3 Sequences Required To Relieve Negative Ure2 Regulation and Support Nuclear Gln3 Import in Saccharomyces cerevisiae.

Identifieur interne : 000544 ( Main/Exploration ); précédent : 000543; suivant : 000545

More than One Way in: Three Gln3 Sequences Required To Relieve Negative Ure2 Regulation and Support Nuclear Gln3 Import in Saccharomyces cerevisiae.

Auteurs : Jennifer J. Tate [États-Unis] ; Rajendra Rai [États-Unis] ; Terrance G. Cooper [États-Unis]

Source :

Genetics [ 1943-2631 ] ; 2018.

RBID : pubmed:29113979

Descripteurs français

English descriptors

KwdEn :
- Active Transport, Cell Nucleus (MeSH), Amino Acid Sequence (MeSH), Computational Biology (methods), Epistasis, Genetic (MeSH), Gene Expression Regulation, Fungal (MeSH), Glutathione Peroxidase (genetics), Nuclear Localization Signals (MeSH), Prions (genetics), Protein Binding (MeSH), Protein Interaction Domains and Motifs (MeSH), Protein Transport (MeSH), Repetitive Sequences, Nucleic Acid (MeSH), Saccharomyces cerevisiae (genetics), Saccharomyces cerevisiae (metabolism), Saccharomyces cerevisiae Proteins (chemistry), Saccharomyces cerevisiae Proteins (genetics), Saccharomyces cerevisiae Proteins (metabolism), Transcription Factors (chemistry), Transcription Factors (genetics), Transcription Factors (metabolism).
MESH :
- chemical , chemistry : Saccharomyces cerevisiae Proteins, Transcription Factors.
- chemical , genetics : Glutathione Peroxidase, Prions, Saccharomyces cerevisiae Proteins, Transcription Factors.
- genetics : Saccharomyces cerevisiae.
- metabolism : Saccharomyces cerevisiae, Saccharomyces cerevisiae Proteins, Transcription Factors.
- methods : Computational Biology.
- Active Transport, Cell Nucleus, Amino Acid Sequence, Epistasis, Genetic, Gene Expression Regulation, Fungal, Nuclear Localization Signals, Protein Binding, Protein Interaction Domains and Motifs, Protein Transport, Repetitive Sequences, Nucleic Acid.

Abstract

Gln3 is responsible for Nitrogen Catabolite Repression-sensitive transcriptional activation in the yeast Saccharomyces cerevisiae In nitrogen-replete medium, Gln3 is cytoplasmic and NCR-sensitive transcription is repressed. In nitrogen-limiting medium, in cells treated with TorC1 inhibitor, rapamycin, or the glutamine synthetase inhibitor, methionine sulfoximine (Msx), Gln3 becomes highly nuclear and NCR-sensitive transcription derepressed. Previously, nuclear Gln3 localization was concluded to be mediated by a single nuclear localization sequence, NLS1. Here, we show that nuclear Gln3-Myc¹³ localization is significantly more complex than previously appreciated. We identify three Gln3 sequences, other than NLS1, that are highly required for nuclear Gln3-Myc¹³ localization. Two of these sequences exhibit characteristics of monopartite (K/R-Rich NLS) and bipartite (S/R NLS) NLSs, respectively. Mutations altering these sequences are partially epistatic to a ure2Δ. The third sequence, the Ure2 relief sequence, exhibits no predicted NLS homology and is only necessary when Ure2 is present. Substitution of the basic amino acid repeats in the Ure2 relief sequence or phosphomimetic aspartate substitutions for the serine residues between them abolishes nuclear Gln3-Myc¹³ localization in response to both limiting nitrogen and rapamycin treatment. In contrast, Gln3-Myc¹³ responses are normal in parallel serine-to-alanine substitution mutants. These observations suggest that Gln3 responses to specific nitrogen environments likely occur in multiple steps that can be genetically separated. At least one general step that is associated with the Ure2 relief sequence may be prerequisite for responses to the specific stimuli of growth in poor nitrogen sources and rapamycin inhibition of TorC1.

DOI: 10.1534/genetics.117.300457
PubMed: 29113979
PubMed Central: PMC5753859

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 000687
to stream Main, to step Curation: 000687

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">More than One Way in: Three Gln3 Sequences Required To Relieve Negative Ure2 Regulation and Support Nuclear Gln3 Import in <i>Saccharomyces cerevisiae</i>
.</title>
<author><name sortKey="Tate, Jennifer J" sort="Tate, Jennifer J" uniqKey="Tate J" first="Jennifer J" last="Tate">Jennifer J. Tate</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology, Immunology and Biochemistry, University of Tennessee Health Science Center, Memphis, Tennessee 38163.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Tennessee</region>
</placeName>
<wicri:cityArea>Department of Microbiology, Immunology and Biochemistry, University of Tennessee Health Science Center, Memphis</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Rai, Rajendra" sort="Rai, Rajendra" uniqKey="Rai R" first="Rajendra" last="Rai">Rajendra Rai</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology, Immunology and Biochemistry, University of Tennessee Health Science Center, Memphis, Tennessee 38163.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Tennessee</region>
</placeName>
<wicri:cityArea>Department of Microbiology, Immunology and Biochemistry, University of Tennessee Health Science Center, Memphis</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Cooper, Terrance G" sort="Cooper, Terrance G" uniqKey="Cooper T" first="Terrance G" last="Cooper">Terrance G. Cooper</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology, Immunology and Biochemistry, University of Tennessee Health Science Center, Memphis, Tennessee 38163 tcooper@uthsc.edu.</nlm:affiliation>
<country wicri:rule="url">États-Unis</country>
<wicri:regionArea>Department of Microbiology, Immunology and Biochemistry, University of Tennessee Health Science Center, Memphis</wicri:regionArea>
<wicri:noRegion>Memphis</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2018">2018</date>
<idno type="RBID">pubmed:29113979</idno>
<idno type="pmid">29113979</idno>
<idno type="doi">10.1534/genetics.117.300457</idno>
<idno type="pmc">PMC5753859</idno>
<idno type="wicri:Area/Main/Corpus">000687</idno>
<idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000687</idno>
<idno type="wicri:Area/Main/Curation">000687</idno>
<idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000687</idno>
<idno type="wicri:Area/Main/Exploration">000687</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">More than One Way in: Three Gln3 Sequences Required To Relieve Negative Ure2 Regulation and Support Nuclear Gln3 Import in <i>Saccharomyces cerevisiae</i>
.</title>
<author><name sortKey="Tate, Jennifer J" sort="Tate, Jennifer J" uniqKey="Tate J" first="Jennifer J" last="Tate">Jennifer J. Tate</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology, Immunology and Biochemistry, University of Tennessee Health Science Center, Memphis, Tennessee 38163.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Tennessee</region>
</placeName>
<wicri:cityArea>Department of Microbiology, Immunology and Biochemistry, University of Tennessee Health Science Center, Memphis</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Rai, Rajendra" sort="Rai, Rajendra" uniqKey="Rai R" first="Rajendra" last="Rai">Rajendra Rai</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology, Immunology and Biochemistry, University of Tennessee Health Science Center, Memphis, Tennessee 38163.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Tennessee</region>
</placeName>
<wicri:cityArea>Department of Microbiology, Immunology and Biochemistry, University of Tennessee Health Science Center, Memphis</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Cooper, Terrance G" sort="Cooper, Terrance G" uniqKey="Cooper T" first="Terrance G" last="Cooper">Terrance G. Cooper</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology, Immunology and Biochemistry, University of Tennessee Health Science Center, Memphis, Tennessee 38163 tcooper@uthsc.edu.</nlm:affiliation>
<country wicri:rule="url">États-Unis</country>
<wicri:regionArea>Department of Microbiology, Immunology and Biochemistry, University of Tennessee Health Science Center, Memphis</wicri:regionArea>
<wicri:noRegion>Memphis</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j">Genetics</title>
<idno type="eISSN">1943-2631</idno>
<imprint><date when="2018" type="published">2018</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Active Transport, Cell Nucleus (MeSH)</term>
<term>Amino Acid Sequence (MeSH)</term>
<term>Computational Biology (methods)</term>
<term>Epistasis, Genetic (MeSH)</term>
<term>Gene Expression Regulation, Fungal (MeSH)</term>
<term>Glutathione Peroxidase (genetics)</term>
<term>Nuclear Localization Signals (MeSH)</term>
<term>Prions (genetics)</term>
<term>Protein Binding (MeSH)</term>
<term>Protein Interaction Domains and Motifs (MeSH)</term>
<term>Protein Transport (MeSH)</term>
<term>Repetitive Sequences, Nucleic Acid (MeSH)</term>
<term>Saccharomyces cerevisiae (genetics)</term>
<term>Saccharomyces cerevisiae (metabolism)</term>
<term>Saccharomyces cerevisiae Proteins (chemistry)</term>
<term>Saccharomyces cerevisiae Proteins (genetics)</term>
<term>Saccharomyces cerevisiae Proteins (metabolism)</term>
<term>Transcription Factors (chemistry)</term>
<term>Transcription Factors (genetics)</term>
<term>Transcription Factors (metabolism)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Biologie informatique (méthodes)</term>
<term>Facteurs de transcription (composition chimique)</term>
<term>Facteurs de transcription (génétique)</term>
<term>Facteurs de transcription (métabolisme)</term>
<term>Glutathione peroxidase (génétique)</term>
<term>Liaison aux protéines (MeSH)</term>
<term>Motifs et domaines d'intéraction protéique (MeSH)</term>
<term>Prions (génétique)</term>
<term>Protéines de Saccharomyces cerevisiae (composition chimique)</term>
<term>Protéines de Saccharomyces cerevisiae (génétique)</term>
<term>Protéines de Saccharomyces cerevisiae (métabolisme)</term>
<term>Régulation de l'expression des gènes fongiques (MeSH)</term>
<term>Saccharomyces cerevisiae (génétique)</term>
<term>Saccharomyces cerevisiae (métabolisme)</term>
<term>Signaux de localisation nucléaire (MeSH)</term>
<term>Séquence d'acides aminés (MeSH)</term>
<term>Séquences répétées d'acides nucléiques (MeSH)</term>
<term>Transport des protéines (MeSH)</term>
<term>Transport nucléaire actif (MeSH)</term>
<term>Épistasie (MeSH)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Saccharomyces cerevisiae Proteins</term>
<term>Transcription Factors</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Glutathione Peroxidase</term>
<term>Prions</term>
<term>Saccharomyces cerevisiae Proteins</term>
<term>Transcription Factors</term>
</keywords>
<keywords scheme="MESH" qualifier="composition chimique" xml:lang="fr"><term>Facteurs de transcription</term>
<term>Protéines de Saccharomyces cerevisiae</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Saccharomyces cerevisiae</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Facteurs de transcription</term>
<term>Glutathione peroxidase</term>
<term>Prions</term>
<term>Protéines de Saccharomyces cerevisiae</term>
<term>Saccharomyces cerevisiae</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Saccharomyces cerevisiae</term>
<term>Saccharomyces cerevisiae Proteins</term>
<term>Transcription Factors</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Computational Biology</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Facteurs de transcription</term>
<term>Protéines de Saccharomyces cerevisiae</term>
<term>Saccharomyces cerevisiae</term>
</keywords>
<keywords scheme="MESH" qualifier="méthodes" xml:lang="fr"><term>Biologie informatique</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Active Transport, Cell Nucleus</term>
<term>Amino Acid Sequence</term>
<term>Epistasis, Genetic</term>
<term>Gene Expression Regulation, Fungal</term>
<term>Nuclear Localization Signals</term>
<term>Protein Binding</term>
<term>Protein Interaction Domains and Motifs</term>
<term>Protein Transport</term>
<term>Repetitive Sequences, Nucleic Acid</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Liaison aux protéines</term>
<term>Motifs et domaines d'intéraction protéique</term>
<term>Régulation de l'expression des gènes fongiques</term>
<term>Signaux de localisation nucléaire</term>
<term>Séquence d'acides aminés</term>
<term>Séquences répétées d'acides nucléiques</term>
<term>Transport des protéines</term>
<term>Transport nucléaire actif</term>
<term>Épistasie</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Gln3 is responsible for Nitrogen Catabolite Repression-sensitive transcriptional activation in the yeast <i>Saccharomyces cerevisiae</i>
 In nitrogen-replete medium, Gln3 is cytoplasmic and NCR-sensitive transcription is repressed. In nitrogen-limiting medium, in cells treated with TorC1 inhibitor, rapamycin, or the glutamine synthetase inhibitor, methionine sulfoximine (Msx), Gln3 becomes highly nuclear and NCR-sensitive transcription derepressed. Previously, nuclear Gln3 localization was concluded to be mediated by a single nuclear localization sequence, NLS1. Here, we show that nuclear Gln3-Myc<sup>13</sup>
 localization is significantly more complex than previously appreciated. We identify three Gln3 sequences, other than NLS1, that are highly required for nuclear Gln3-Myc<sup>13</sup>
 localization. Two of these sequences exhibit characteristics of monopartite (K/R-Rich NLS) and bipartite (S/R NLS) NLSs, respectively. Mutations altering these sequences are partially epistatic to a <i>ure2</i>
Δ. The third sequence, the Ure2 relief sequence, exhibits no predicted NLS homology and is only necessary when Ure2 is present. Substitution of the basic amino acid repeats in the Ure2 relief sequence or phosphomimetic aspartate substitutions for the serine residues between them abolishes nuclear Gln3-Myc<sup>13</sup>
 localization in response to both limiting nitrogen and rapamycin treatment. In contrast, Gln3-Myc<sup>13</sup>
 responses are normal in parallel serine-to-alanine substitution mutants. These observations suggest that Gln3 responses to specific nitrogen environments likely occur in multiple steps that can be genetically separated. At least one general step that is associated with the Ure2 relief sequence may be prerequisite for responses to the specific stimuli of growth in poor nitrogen sources and rapamycin inhibition of TorC1.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">29113979</PMID>
<DateCompleted><Year>2018</Year>
<Month>10</Month>
<Day>02</Day>
</DateCompleted>
<DateRevised><Year>2019</Year>
<Month>01</Month>
<Day>07</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1943-2631</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>208</Volume>
<Issue>1</Issue>
<PubDate><Year>2018</Year>
<Month>01</Month>
</PubDate>
</JournalIssue>
<Title>Genetics</Title>
<ISOAbbreviation>Genetics</ISOAbbreviation>
</Journal>
<ArticleTitle>More than One Way in: Three Gln3 Sequences Required To Relieve Negative Ure2 Regulation and Support Nuclear Gln3 Import in <i>Saccharomyces cerevisiae</i>
.</ArticleTitle>
<Pagination><MedlinePgn>207-227</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1534/genetics.117.300457</ELocationID>
<Abstract><AbstractText>Gln3 is responsible for Nitrogen Catabolite Repression-sensitive transcriptional activation in the yeast <i>Saccharomyces cerevisiae</i>
 In nitrogen-replete medium, Gln3 is cytoplasmic and NCR-sensitive transcription is repressed. In nitrogen-limiting medium, in cells treated with TorC1 inhibitor, rapamycin, or the glutamine synthetase inhibitor, methionine sulfoximine (Msx), Gln3 becomes highly nuclear and NCR-sensitive transcription derepressed. Previously, nuclear Gln3 localization was concluded to be mediated by a single nuclear localization sequence, NLS1. Here, we show that nuclear Gln3-Myc<sup>13</sup>
 localization is significantly more complex than previously appreciated. We identify three Gln3 sequences, other than NLS1, that are highly required for nuclear Gln3-Myc<sup>13</sup>
 localization. Two of these sequences exhibit characteristics of monopartite (K/R-Rich NLS) and bipartite (S/R NLS) NLSs, respectively. Mutations altering these sequences are partially epistatic to a <i>ure2</i>
Δ. The third sequence, the Ure2 relief sequence, exhibits no predicted NLS homology and is only necessary when Ure2 is present. Substitution of the basic amino acid repeats in the Ure2 relief sequence or phosphomimetic aspartate substitutions for the serine residues between them abolishes nuclear Gln3-Myc<sup>13</sup>
 localization in response to both limiting nitrogen and rapamycin treatment. In contrast, Gln3-Myc<sup>13</sup>
 responses are normal in parallel serine-to-alanine substitution mutants. These observations suggest that Gln3 responses to specific nitrogen environments likely occur in multiple steps that can be genetically separated. At least one general step that is associated with the Ure2 relief sequence may be prerequisite for responses to the specific stimuli of growth in poor nitrogen sources and rapamycin inhibition of TorC1.</AbstractText>
<CopyrightInformation>Copyright © 2018 by the Genetics Society of America.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Tate</LastName>
<ForeName>Jennifer J</ForeName>
<Initials>JJ</Initials>
<AffiliationInfo><Affiliation>Department of Microbiology, Immunology and Biochemistry, University of Tennessee Health Science Center, Memphis, Tennessee 38163.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Rai</LastName>
<ForeName>Rajendra</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>Department of Microbiology, Immunology and Biochemistry, University of Tennessee Health Science Center, Memphis, Tennessee 38163.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Cooper</LastName>
<ForeName>Terrance G</ForeName>
<Initials>TG</Initials>
<AffiliationInfo><Affiliation>Department of Microbiology, Immunology and Biochemistry, University of Tennessee Health Science Center, Memphis, Tennessee 38163 tcooper@uthsc.edu.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<GrantList CompleteYN="Y"><Grant><GrantID>R01 GM035642</GrantID>
<Acronym>GM</Acronym>
<Agency>NIGMS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
</GrantList>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2017</Year>
<Month>11</Month>
<Day>07</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>Genetics</MedlineTA>
<NlmUniqueID>0374636</NlmUniqueID>
<ISSNLinking>0016-6731</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C071664">GLN3 protein, S cerevisiae</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D019913">Nuclear Localization Signals</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D011328">Prions</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D029701">Saccharomyces cerevisiae Proteins</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D014157">Transcription Factors</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 1.11.1.9</RegistryNumber>
<NameOfSubstance UI="D005979">Glutathione Peroxidase</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 1.11.1.9</RegistryNumber>
<NameOfSubstance UI="C067020">URE2 protein, S cerevisiae</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D021581" MajorTopicYN="N">Active Transport, Cell Nucleus</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000595" MajorTopicYN="N">Amino Acid Sequence</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D019295" MajorTopicYN="N">Computational Biology</DescriptorName>
<QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004843" MajorTopicYN="N">Epistasis, Genetic</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015966" MajorTopicYN="Y">Gene Expression Regulation, Fungal</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005979" MajorTopicYN="N">Glutathione Peroxidase</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D019913" MajorTopicYN="N">Nuclear Localization Signals</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011328" MajorTopicYN="N">Prions</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011485" MajorTopicYN="N">Protein Binding</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D054730" MajorTopicYN="N">Protein Interaction Domains and Motifs</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D021381" MajorTopicYN="N">Protein Transport</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012091" MajorTopicYN="N">Repetitive Sequences, Nucleic Acid</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012441" MajorTopicYN="N">Saccharomyces cerevisiae</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D029701" MajorTopicYN="N">Saccharomyces cerevisiae Proteins</DescriptorName>
<QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName>
<QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014157" MajorTopicYN="N">Transcription Factors</DescriptorName>
<QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName>
<QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">Gln3</Keyword>
<Keyword MajorTopicYN="Y">NLS</Keyword>
<Keyword MajorTopicYN="Y">TorC1</Keyword>
<Keyword MajorTopicYN="Y">Ure2</Keyword>
<Keyword MajorTopicYN="Y">methionine sulfoximine</Keyword>
<Keyword MajorTopicYN="Y">nitrogen catabolite repression</Keyword>
<Keyword MajorTopicYN="Y">nuclear localization sequence</Keyword>
<Keyword MajorTopicYN="Y">rapamycin</Keyword>
</KeywordList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2017</Year>
<Month>09</Month>
<Day>29</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2017</Year>
<Month>11</Month>
<Day>02</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2017</Year>
<Month>11</Month>
<Day>9</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2018</Year>
<Month>10</Month>
<Day>3</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2017</Year>
<Month>11</Month>
<Day>9</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">29113979</ArticleId>
<ArticleId IdType="pii">genetics.117.300457</ArticleId>
<ArticleId IdType="doi">10.1534/genetics.117.300457</ArticleId>
<ArticleId IdType="pmc">PMC5753859</ArticleId>
</ArticleIdList>
<ReferenceList><Reference><Citation>J Bacteriol. 1996 Aug;178(15):4734-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">8755910</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Bacteriol. 1972 Jan;109(1):203-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">4550662</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Genetics. 2012 Sep;192(1):73-105</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22964838</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>EMBO J. 1999 May 17;18(10 ):2782-92</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10329624</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 2001 Aug 24;276(34):32136-44</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11408486</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 2017 Feb 17;292(7):2660-2669</Citation>
<ArticleIdList><ArticleId IdType="pubmed">28057755</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Genetics. 2012 Mar;190(3):885-929</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22419079</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>FEMS Yeast Res. 2014 Feb;14(1):17-32</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24102693</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Genetics. 2015 Nov;201(3):989-1016</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26333687</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 2011 Dec 30;286(52):44897-912</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22039046</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>G3 (Bethesda). 2016 May 03;6(5):1391-408</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26976442</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 2009 Jan 23;284(4):2522-34</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19015262</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 2013 Jan 18;288(3):1841-55</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23184930</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>BMC Bioinformatics. 2009 Jun 29;10:202</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19563654</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nucleic Acids Res. 2007 Jul;35(Web Server issue):W460-4</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17567614</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Bacteriol. 1971 May;106(2):519-22</Citation>
<ArticleIdList><ArticleId IdType="pubmed">5573734</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS Genet. 2015 Feb 19;11(2):e1004991</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25695491</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>FEMS Yeast Res. 2006 Mar;6(2):218-29</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16487345</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 2000 Nov 17;275(46):35727-33</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10940301</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nature. 1999 Dec 9;402(6762):689-92</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10604478</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mol Cell. 2009 Sep 11;35(5):563-73</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19748353</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Genetics. 2017 Feb;205(2):633-655</Citation>
<ArticleIdList><ArticleId IdType="pubmed">28007891</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nucleic Acids Res. 2010 Jan;38(Database issue):D161-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19858104</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mol Cell. 2012 Apr 13;46(1):105-10</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22424774</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Annu Rev Microbiol. 2005;59:407-50</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16153175</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mol Biotechnol. 1999 Aug;12(1):35-73</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10554772</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>G3 (Bethesda). 2015 May 29;5(8):1625-38</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26024867</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mol Cell Biol. 2011 Jan;31(1):92-104</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20974806</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Bacteriol. 1994 Dec;176(24):7476-83</Citation>
<ArticleIdList><ArticleId IdType="pubmed">8002570</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 2004 Mar 12;279(11):10270-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">14679193</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 2000 May 12;275(19):14408-14</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10799523</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 2014 Jul 4;289(27):18999-9018</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24847055</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 2010 May 28;285(22):16893-911</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20233714</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Genes Dev. 2003 Apr 1;17(7):859-72</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12654728</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Biochem Biophys Res Commun. 1973 Jul 17;53(2):367-72</Citation>
<ArticleIdList><ArticleId IdType="pubmed">4146147</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Bacteriol. 1988 Feb;170(2):708-13</Citation>
<ArticleIdList><ArticleId IdType="pubmed">2892826</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 2003 May 9;278(19):16878-86</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12624103</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Genes Dev. 1996 Aug 1;10(15):1904-16</Citation>
<ArticleIdList><ArticleId IdType="pubmed">8756348</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>FEMS Microbiol Rev. 2014 Mar;38(2):254-99</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24483210</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mol Biol Cell. 2003 Nov;14(11):4342-51</Citation>
<ArticleIdList><ArticleId IdType="pubmed">14551259</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>EMBO J. 2017 Feb 15;36(4):397-408</Citation>
<ArticleIdList><ArticleId IdType="pubmed">28096180</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 2006 Dec 8;281(49):37980-92</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17015442</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 2013 Jan 25;288(4):2789-804</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23223232</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>FEMS Microbiol Rev. 2002 Aug;26(3):223-38</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12165425</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Eukaryot Cell. 2014 Apr;13(4):527-38</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24562911</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>EMBO J. 2006 Aug 9;25(15):3546-55</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16874307</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell Cycle. 2010 Jan 15;9(2):221-2</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20023374</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 2009 Jun 23;106(25):10171-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19520826</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 2010 Jun 4;285(23):17880-95</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20378536</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 2013 Sep 20;288(38):27243-62</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23935103</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Gene. 2002 May 15;290(1-2):1-18</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12062797</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Bacteriol. 1983 Jan;153(1):163-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">6336730</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>États-Unis</li>
</country>
<region><li>Tennessee</li>
</region>
</list>
<tree><country name="États-Unis"><region name="Tennessee"><name sortKey="Tate, Jennifer J" sort="Tate, Jennifer J" uniqKey="Tate J" first="Jennifer J" last="Tate">Jennifer J. Tate</name>
</region>
<name sortKey="Cooper, Terrance G" sort="Cooper, Terrance G" uniqKey="Cooper T" first="Terrance G" last="Cooper">Terrance G. Cooper</name>
<name sortKey="Rai, Rajendra" sort="Rai, Rajendra" uniqKey="Rai R" first="Rajendra" last="Rai">Rajendra Rai</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Bois/explor/RapamycinFungusV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000544 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000544 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Bois
   |area=    RapamycinFungusV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     pubmed:29113979
   |texte=   More than One Way in: Three Gln3 Sequences Required To Relieve Negative Ure2 Regulation and Support Nuclear Gln3 Import in Saccharomyces cerevisiae.
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:29113979" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a RapamycinFungusV1

This area was generated with Dilib version V0.6.38.
Data generation: Thu Nov 19 21:55:41 2020. Site generation: Thu Nov 19 22:00:39 2020

	Serveur d'exploration sur la rapamycine et les champignons
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration sur la rapamycine et les champignons

More than One Way in: Three Gln3 Sequences Required To Relieve Negative Ure2 Regulation and Support Nuclear Gln3 Import in Saccharomyces cerevisiae.

More than One Way in: Three Gln3 Sequences Required To Relieve Negative Ure2 Regulation and Support Nuclear Gln3 Import in Saccharomyces cerevisiae.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki